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Description: Traditionally, yoga is a multicomponent practice consisting of postures, breathing techniques, meditation, and ethics. To date, only a few studies have tried to dismantle the effects of each of these components and their combinations. To fill this gap, we examined the incremental effects of ethical education and physical yoga on mantra meditation using a single-case multiple-baseline design. This study was part of a project evaluating the new mind–body program Meditation-Based Lifestyle Modification. Forty-two healthy participants were randomly assigned to four conditions—meditation alone, meditation plus physical yoga, meditation plus ethical education, and meditation plus yoga and ethics. All the interventions lasted for 8 weeks and were run consecutively according to baseline length. During the baseline and treatment phases, participants received daily questionnaires measuring their well-being, perceived stress, and subjective experiences. We analyzed our data using visual inspection, effect size estimation (Tau-U), and multilevel modeling. Almost all participants showed an increase in well-being, except participants in the meditation-only condition. This increase was most prominent in participants who received ethical education. There was a tendency for all treatments to decrease stress. However, there was a marked reduction in stress for participants in the yoga-plus-meditation condition. These results emphasize the incremental and differential effects of practicing meditation in combination with other practices from the eightfold yoga path. This approach is valuable for better understanding the multifaceted practice of yoga. Has data, scripts, and supplemental materials for "What Makes Yoga Effective? Differential Effects of Ethical Education, Physical Yoga, and Mantra Meditation on Well-Being and Stress" on PsyArXiv: https://psyarxiv.com/nr2qg/