**Summary of this project:** The full review of literature on men’s and boys' barriers to health system access and opportunities for health system engagement can be accessed at the Australian Government Department of Health and Aged Care. https://www.health.gov.au/sites/default/files/2023-07/men-s-and-boys-barriers-to-health-system-access-a-literature-review.pdf **The citation for the review is:** Macdonald, J.A., Mansour, K.A, Wynter, K., Francis, L. M., Rogers, A., Angeles, M.R., Pennell, M., Biden, E., Harrison, T., & Smith, I. (2022). Men’s and Boys’ Barriers to Health System Access. A Literature Review. https://www.health.gov.au/sites/default/files/2023-07/men-s-and-boys-barriers-to-health-system-access-a-literature-review.pdf The extracted data file is available for download here on the Open Science Framework website in line with the National Health and Medical Research Council of Australia’s Open Access Policy. The search of databases was conducted on October 21, 2019. Research published after that date is not included. **Note:** In total 747 articles were included in the review comprising 412 Australian studies and 335 reviews of international literature. Care was taken to accurately input data from the included articles into the Data Extraction Workbook but transcription errors may have occurred. Please report discrepancies to the corresponding author.